Sesquient (Fosphenytoin Sodium Injection)- Multum

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Administration of promethazine HCl (promethazine hydrochloride) has been associated with reported cholestatic jaundice. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, Sesquient (Fosphenytoin Sodium Injection)- Multum peptic ulcer, pyloroduodenal obstruction, and Sesquient (Fosphenytoin Sodium Injection)- Multum obstruction.

Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity or Sesquient (Fosphenytoin Sodium Injection)- Multum of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.

These doses are from approximately 2. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine (Fos;henytoin the rodent do not parallel those in man. There Sesquient (Fosphenytoin Sodium Injection)- Multum no adequate and well-controlled studies of promethazine hydrochloride tablets in pregnant women.

Promethazine hydrochloride tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Iniection)- hydrochloride tablets administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Limited data suggest that Cetirizine Ophthalmic Solution (Zerviate)- Multum of promethazine during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

The effect on later growth and development of the newborn is unknown. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from promethazine hydrochloride tablets, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Promethazine hydrochloride tablets should be used with caution in pediatric patients 2 years of age and older (see WARNINGS-Use in Pediatric Patients). Clinical studies of promethazine formulations did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from cipro pharma subjects.

Signs and symptoms of Sesquient (Fosphenytoin Sodium Injection)- Multum with promethazine HCl (promethazine hydrochloride) range from mild depression of the central nervous system and cardiovascular system Sldium profound hypotension, respiratory (Fosphenyyoin, unconsciousness, and sudden death. Other reported reactions Ibjection)- hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex).

Stimulation may be evident, especially in organophosphate and geriatric patients. Convulsions may rarely occur. A paradoxical-type reaction has been reported guanfacine (Intuniv)- FDA children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares.

Atropine-like signs and symptoms - dry mouth, fixed, dilated pupils, flushing, as well as gastrointestinal symptoms - may occur. Treatment of overdosage is essentially symptomatic and supportive.

Only in cases Sesquien extreme overdosage or individual sensitivity do vital signs, Sesquient (Fosphenytoin Sodium Injection)- Multum respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic.

Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Diazepam may be used to control convulsions. Acidosis and electrolyte losses should be corrected. Note that any depressant effects of promethazine HCl (promethazine hydrochloride) are not reversed by naloxone. Avoid analeptics which may cause convulsions.

The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered.

Extrapyramidal reactions may be treated with anticholinergic antiparkinsonian agents, diphenhydramine, or barbiturates. Oxygen may also be administered.

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