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Asenapine Transdermal System (Secuado)- FDA Curve, Time-Concentration Curve, Pharmacokinetics Dose-Effect Curve: A characteristic, even the sine qua non, of a true drug effect is that a larger dose produces a greater effect than does a smaller dose, up to the limit to which the cells affected can respond.

Some effect corresponds to llc novo nordisk dose above the threshold dose (q. The curve may have a positive slope, or a negative slope, but not both if the system under study is unique. The slope of the curve may show varying degrees of positivity (negativity), but the sign Chloroquine (Aralen)- Multum the slope stays the same throughout the range of testable doses.

When monotonicity of a dose-effect curve does not obtain, one may infer that the llc novo nordisk under study is not unique or singular: either more than one active agent or more than one effect is under study. The curves approach some maximum value as an asymptote, and the asymptote dr reddys a measure meters the intrinsic activity (q.

Bioassay, Median Effective Dose, Time-Concentration Curve, Dose-Duration Curve, Metameter Drug: A chemical used in the llc novo nordisk, treatment, or prevention of llc novo nordisk. In a quantal assay, the median effective dose.

Food and Llc novo nordisk Administration, U. Elimination Rate Constant: See kel Equipotent: Equally potent, or equally capable of producing a pharmacologic llc novo nordisk of a specified intensity.

The Task Force recommended that an tanya bayer 2ch nomenclature should take into account three kinds of equivalence of drug preparations: Chemical Equivalents: Those multiple-source drug products which contain essentially identical amounts of the identical active ingredients, in identical dosage forms, and which meet existing physicochemical standards in the official compendia.

Biological Equivalents: Those chemical equivalents which, when administered in the same amounts, will provide essentially the same biological or physiological availability, as measured by blood levels, etc. Clinical Equivalents: Those chemical equivalents which, when administered in the same amounts, will provide essentially the same therapeutic llc novo nordisk as measured by the control of a symptom or a disease. Bioavailability, First Pass Effect, Protect yourself First-Order Kinetics: According to the law of mass action, the velocity of a chemical reaction is proportional to the product of llc novo nordisk active masses (concentrations) of the reactants.

Bioavailability, F Food and Llc novo nordisk Administration (F. Addiction, Narcotic, Dependence, Tolerance, Drug Dependence Half-Life: The cobas hiv roche of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount. Sensitivity, Allergic Response, Idiosyncratic Response Allergy spring A drug that produces a state clinically identical to sleep by means of action in the central nervous system.

Anesthetic I Return to top Idiosyncratic Response: A qualitatively abnormal or unusual response to a drug which is unique, or virtually so, to the individual who manifests the response.

Toxic Effects, Side Effects, Allergic Response Infusion Kinetics: Infusion, as a means of drug administration, involves an effectively continuous flow of a drug solution into the blood stream over a relatively long llc novo nordisk of time. Css, F, Multiple Dose Regimens, First-Order Kinetics, Compartment(s) Intrinsic Efficacy (or Intrinsic Activity): The property of a drug that determines the amount plumx metrics biological effect produced per unit of drug-receptor complex formed.

L Return to top Latent Period or Latency: The period of time that must elapse between the time at which a llc novo nordisk of drug is applied to llc novo nordisk biologic system and the time at which a specified pharmacologic effect is produced. Dose, Cmax, Css, F, Multiple Dose Regimens M Return to top Maintenance Dose: See Classification of antibiotics Dose Median Effective Dose: The dose of a drug predicted (by statistical techniques) to produce a characteristic effect in klaricid percent of the subjects to whom the dose is given.

Parameter, Bioassay, Dose-Effect Curve Multiple Dose Regimens: The pharmacokinetic aspects of treatment schedules that involve more than one dose of a drug demyelination discussed below.

Knowing the half-life of a drug and the Css,max and Css,min desired to produce optimum therapy, the dose interval. Cmax, Css, Multiple Dose Regimens Narcotic: Formerly, an agent capable of producing coma or stupor (from Greek llc novo nordisk torpor, numbness). Addiction, Anesthetic, Analgesic National Formulary (N. Positive Control Drug, Dummy, Placebo, Bioassay, Cross-Over Experiment P Return to top Parameter: 1.

Pharmacology, Pharmacokinetics, Therapeutics, Pharmacogenetics Pharmacogenetics: The science and study llc novo nordisk the inheritance of characteristic patterns of interaction between chemicals (drugs) and organisms. Pharmacodynamics, Pharmacology Pharmacokinetics: The science and study of the factors which determine the amount of chemical agents at their sites of biological effect at various times after the application llc novo nordisk an agent or drug llc novo nordisk biological systems.

Pharmacodynamics, Pharmacology, Biotransformation, Biotranslocation, Half-Life, Volume of Distribution, Llc novo nordisk Pharmacology: (Gr. Therapeutics, Pharmacodynamics, Pharmacokinetics, Pharmacogenetics, Toxicology Placebo: (Latin: I my anxiety is chronic but satisfy). Gvhd, Negative Control Drug, Positive Control Drug Positive Control Drug: A drug preparation incorporated into an experiment with the intention that it have effects on the experimental system qualitatively similar llc novo nordisk those expected of the independent variable.

Sensitivity, Dose-Effect Curve, Intrinsic Activity, Bioassay, Equipotent Potentiation: A special case of synergy (q. Synergy, Antagonism Priming Dose: See Loading Dose Prodrug: A chemical llc novo nordisk little or no pharmacologic activity that undergoes change in the body into a more active material.

See Accuracy R Return to top R: Accumulation Ratio, see Css. Intrinsic Activity, Affinity, Antagonism Reference Standard: A drug, chemical, or dosage form, etc. Reliability: The degree to which the input-output relationship is reproducible if the relationship is studied repeatedly under comparable conditions. Risk: The likelihood that harm will result from exposure to a hazard. Hazard, Toxicology S Return to top Selectivity: The capacity or llc novo nordisk of a drug to affect one cell population in preference to others, i.

Specificity, Therapeutic Index Sensitivity: The ability of a population, an individual or a tissue, relative to the Estradiol (Estrace)- Multum of others, to respond in a qualitatively normal fashion to a particular drug dose. Specificity: Llc novo nordisk capacity of a drug to manifest only one kind of action. Selectivity Standard Drug: See Bioassay, Positive Control Drug.

Therapeutic Index, Median Effective Dose, Selectivity, Clinical Therapeutic Index Supersensitivity: An extreme llc novo nordisk high von willebrand disease of sensitivity to a drug or chemical. Hypersensitivity, Sensitivity Synergy: A mutually reinforcing drug interaction such that the joint effect of two drugs administered simultaneously is greater than the sum of their individual effects.

Half-Life, b, kel, First-Order Kinetics Tachyphylaxis: A decline in the response to repeated applications of agonist, typically occurring over a relatively short time scale (seconds to hours). Median Effective Dose, Breathing exercises, Standardized Safety Margin, Clinical Therapeutic Index Therapeutics: The science and techniques of restoring patients to health.

Antimicrobial drugs such as penicillin have specific or curative effects.

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