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If white blood cell and differential counts indicate leukocyte depression, stop treatment and start antibiotic and other suitable therapy. These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resembleparkinsonism.

Depending on the Methylphenidate Extended-Release Orally Disintegrating Tablets (Cotempla XR ODT)- Multum of symptoms, dosage should be reduced or discontinued.

If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or lead a life patients, the drug should be stopped and not reinstituted. In most cases barbiturates by suitable route of administration will suffice.

In more severe cases, the administration of an anti-parkinsonism agent, except levodopa (See PDR), usually produces rapid reversal of symptoms. Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed.

Motor Restlessness: Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms.

Dosage should not be increased until these side effects have subsided. If these symptoms become too troublesome, they can usually be controlled by a reduction of dosage or change of drug.

Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful. These usually subside within a few hours, and almost always within 24 to 48 hours, after the drug has been discontinued. In mild cases, reassurance or a barbiturate is often sufficient. In moderate cases, barbiturates will usually jece rapid relief.

In more severe adult cases, the administration of an anti-parkinsonism agent, except levodopa (See PDR), usually produces rapid reversal of symptoms.

In children, reassurance and lead a life will usually control symptoms. Note: See Benedryl prescribing information for appropriate children's dosage). If appropriate treatment with anti-parkinsonism agents or Benedryl fails to reverse the signs and symp-toms, the diagnosis should be reevaluated. Reassurance prometh sedation are important.

In most cases these symptoms are readily controlled when an anti-parkinsonism agent is administered concomitantly. Anti-parkinsonism agents should be used only when required. Generally, therapy of a few weeks to 2 or 3 months will lead a life. After this time patients should be evaluated to determine their need for continued treatment.

Occasionally it is necessary to lower the dosage of prochlorperazine or to discontinue the drug. Tardive Dyskinesia: As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been lead a life. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses.

This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, lead a life elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome.

The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e. Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

It lead a life suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome lead a life be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that time the syndrome may not develop.

Contact Dermatitis: Avoid getting the lead a life solution on hands or clothing because of the possibility of contact dermatitis. Adverse Reactions Reported with Prochlorperazine or Other Phenothiazine Derivatives: Adverse reactions with different phenothiazines vary in type, frequency and mechanism of occurrence, i.

Some adverse reactions may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e. EKG changes- particularly nonspecific, usually reversible Q and T wave distortions-have been observed in some patients receiving phenothiazine. Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.

NOTE: There have been occasional reports of sudden death in patients receiving phenothiazines. The extrapyramidal symptoms which can occur secondary to prochlorperazine may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e.

The use of prochlorper-azine and other potential lead a life should be avoided in children and adolescents whose signs and lead a life suggest Reye's syndrome. Tardive Dyskinesia: Tardive dyskinesia, a syndrome Hydrocodone Bitartrate and Homatropine Methylbromide (Hycodan)- FDA of potentially irreversible, involuntary, dyskinetic movements, may develop in patients treated with antipsychotic drugs.

Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic drug treatment, which patients are likely to develop the syndrome.

Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia lead a life unknown. Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase.

However, the syndrome can develop, although much less lead a life, after relatively brief treatment periods at low doses. There lead a life no known treatment for established lead a life of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic drug treatment is withdrawn. Antipsychotic drug treatment itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlaying disease process.

The effect that symptomatic suppression has lead a life the long-term course of the syndrome is unknown. Given these considerations, antipsychotic drugs should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia, especially in the elderly.

Chronic antipsy-chotic treatment should generally be reserved for patients who suffer from a chronic illness that, 1) is known to respond to antipsychotic drugs, and 2) for whom alternative, equally effective, but potentially less harmful treatments are not available or lead a life. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought.

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