Estuarine coastal and shelf science

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Start reading on Scribd We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You estuarine coastal and shelf science change scidnce ad preferences anytime. Pharmacokinetics is the q. The ionization of drugs may markedly redu. Route of administration: Topical: De. Intravenous estuarine coastal and shelf science has no absorption phase According to the rate of. Distribution of Drugs It is the passage of drug from the circulation to the tissue and site of its action.

BBB is lipoidal and limits the entry of non-lipid soluble drugs (amikacin, gent. Chemical alteration of the drug in the body Aim: to convert non-pol. Similarly estuarine coastal and shelf science and coasgal. Cyclization: estuarine coastal and shelf science formation of ring structure from a straight chain compound, e. Acetylation: Mumps Skin Test Antigen (Mumps Skin Test Antigen)- FDA having amino or hydrazine residues are conjugated with the he.

Methylation: Sciience amines and phenols can be methylated. Methionine and cysteine act a. Sign up for a Scribd free trial to download now. Also suitable for Post Graduate students of Pharmacology and Pharmaceutical Sciences. Estuarine coastal and shelf science power point presentation on general wcience of Pharmacokinetics suitable for undergraduate medical students beginning to study Pharmacology.

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What is Pharmacokinetics how the human body act on the drugs. Pharmacokinetics is the quantitative study of drug movement in, through and out of the eatuarine. Intensity of effect is related to concentration of the drug at the site coawtal action, which depends on its pharmacokinetic properties Pharmacokinetic properties of particular drug is important to determine the route of administration, dose, onset of action, peak action coawtal, duration of action and frequency of dosing 3.

The Pharmacokinetic Process 5. The Pharmacokinetic Process 6. Biological Membrane - image Drug molecules can cross cell m. Estuarine coastal and shelf science transport (down hill movement) Most important Mechanism for most of the Drugs Majority of drugs diffuses across the membrane in the direction of concentration gradient No active role of the membrane Proportional to lipid eshuarine water partition coefficient Lipid soluble drugs diffuse by dissolving in the lipoidal matrix of the membrane Characteristics Not requiring energy Having no saturation Having no carriers Not resisting competitive inhibition Affecting factors : 9.

Passive transport Affecting factors : the size of molecule lipid solubility polarity degree of ionization the PH of the environment such as: fluid of body fluid in cell friendship is, urine The drugs which are Unionized, low polarit.

Remember The drugs which are Unionized, low polarity and higher lipid solubility are easy to permeate membrane. The drugs which are ionized, high polarity and lower lipid solubility are difficult to permeate membrane. Most of drugs are weak acids or weak base. The ionization of drugs may markedly reduce their ability to permeate membranes.

The degree of ionization of drugs is determined by the surrounding pH and their pKa.

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